Notch is required for long-term memory in Drosophila

Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1764-8. doi: 10.1073/pnas.0308259100. Epub 2004 Jan 29.


A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructure. Simultaneously, Presenilin (Psn) was identified both as a key mediator of Notch signaling and as a site of genetic lesions that cause early-onset Alzheimer's disease. Here we demonstrate that Notch loss of function produces memory deficits in Drosophila melanogaster. The effects are specific to long-term memory, which is thought to depend on ultrastructural remodeling. We propose that Notch plays an important role in the neural plasticity underlying consolidated memory.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Conditioning, Classical
  • Drosophila / genetics
  • Drosophila / physiology*
  • Drosophila Proteins
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Memory / physiology*
  • Mutation
  • RNA Interference / physiology
  • Receptors, Notch


  • Drosophila Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch