Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9

Cell Death Differ. 2004 May;11(5):583-7. doi: 10.1038/sj.cdd.4401388.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Apoptosis / drug effects*
  • Apoptosis Regulatory Proteins
  • Caspase 9
  • Caspases / drug effects*
  • Drug Therapy
  • Epithelial Cells / drug effects
  • Esophageal Neoplasms / drug therapy*
  • Humans
  • Membrane Glycoproteins / pharmacology*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*
  • TNF-Related Apoptosis-Inducing Ligand
  • Tumor Necrosis Factor-alpha / pharmacology*
  • bcl-X Protein

Substances

  • Apoptosis Regulatory Proteins
  • BCL2L1 protein, human
  • Membrane Glycoproteins
  • Proto-Oncogene Proteins c-bcl-2
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human
  • Tumor Necrosis Factor-alpha
  • bcl-X Protein
  • CASP9 protein, human
  • Caspase 9
  • Caspases