Effects of physical therapy intervention for children with acute lymphoblastic leukemia

Pediatr Blood Cancer. 2004 Feb;42(2):127-33. doi: 10.1002/pbc.10481.


Background: The purpose of this study was to examine the effects of physical therapy intervention in children with acute lymphoblastic leukemia (ALL).

Procedure: Twenty-eight children aged 4-15 years were randomly assigned to an intervention or control group. The intervention group received five sessions of physical therapy and was instructed to perform an individualized home exercise program consisting of ankle dorsiflexion stretching, lower extremity strengthening, and aerobic exercise.

Results: After 4 months children who received physical therapy intervention had significantly improved ankle dorsiflexion active range of motion and knee extension strength (P < 0.01). Differences were not found between the two groups for any of the other dependent variables.

Conclusions: Physical therapy intervention for children with ALL receiving maintenance chemotherapy improved two body functions important for normal gait. Physical therapy programs initiated earlier in treatment and with greater emphasis on endurance activities may also improve stamina and quality of life (QOL).

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Ankle / physiology
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Exercise Therapy*
  • Exercise*
  • Female
  • Gait / physiology*
  • Humans
  • Knee / physiology
  • Male
  • Physical Endurance
  • Physical Therapy Modalities
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
  • Range of Motion, Articular