Histologic evaluation of human biopsies after dental augmentation with a demineralized bone matrix putty

Implant Dent. 2003;12(4):325-32. doi: 10.1097/01.id.0000095466.18042.31.


To solve some of the problems inherent in bone regeneration, various types of graft materials, matrix, putty, and gel delivery systems have been developed. These deliver demineralized bone matrix (DBM) to a graft site and maintain it in an appropriate position to achieve favorable results. This prospective study reviewed 10 cases of extraction immediate grafting with a putty-DBM delivery system. Five patients were male and 5 female. At intervals ranging from 4 to 21 months postextraction grafting, bone cores were harvested at the time of surgical insertion of Replace endosteal two-stage implants. All patients were restored with single-tooth self-standing prostheses. Bone quality and quantity in each of the bone cores were evaluated. All 10 cases were completed with favorable outcomes.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Bone Density
  • Bone Matrix / transplantation*
  • Bone Regeneration / drug effects*
  • Bone Substitutes / pharmacology
  • Bone Transplantation / methods*
  • Bone Transplantation / physiology
  • Dental Implantation, Endosseous
  • Dental Implants, Single-Tooth
  • Female
  • Humans
  • Male
  • Middle Aged
  • Poloxamer / pharmacology*
  • Surface-Active Agents / pharmacology*
  • Tooth Socket / surgery


  • Bone Substitutes
  • Surface-Active Agents
  • Poloxamer