The effectiveness of 3, 5 or 7 days of albendazole for the treatment of Trichuris trichiura infection

Ann Trop Med Parasitol. 2003 Dec;97(8):847-53. doi: 10.1179/000349803225002480.


A randomized clinical trial was carried out to study the relationship between the duration of albendazole therapy, at 400 mg/day, and its effectiveness in the treatment of Trichuris trichiura infection. The 168 patients were treated for three (N=56), five (N=56) or seven (N=56) consecutive days. Compared with both of the shorter regimens, treatment for 7 days resulted in a significantly higher cure 'rate' and significantly greater reductions in the level of egg excretion. The advantage of using the longer (5- or 7-day) regimens was most apparent among the patients who had heavy infections (at least 1000 Trichuris eggs/g faeces) when treated. It is therefore suggested that albendazole be given for at least 3 days to those with light infections and for 5-7 days to patients with heavy infections.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Albendazole / administration & dosage*
  • Albendazole / adverse effects
  • Analysis of Variance
  • Antinematodal Agents / administration & dosage*
  • Antinematodal Agents / adverse effects
  • Child
  • Drug Administration Schedule
  • Feces / parasitology
  • Female
  • Humans
  • Male
  • Parasite Egg Count / methods
  • Treatment Outcome
  • Trichuriasis / complications
  • Trichuriasis / drug therapy*


  • Antinematodal Agents
  • Albendazole