Central role of the P2Y12 receptor in platelet activation

J Clin Invest. 2004 Feb;113(3):340-5. doi: 10.1172/JCI20986.


Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.

Publication types

  • Review

MeSH terms

  • Adenosine Diphosphate / metabolism
  • Bleeding Time
  • Blood Coagulation / physiology
  • Blood Platelets / metabolism*
  • Humans
  • Membrane Proteins / metabolism*
  • Platelet Activation / physiology*
  • Receptors, Purinergic P2 / metabolism*
  • Receptors, Purinergic P2Y12


  • Membrane Proteins
  • P2RY12 protein, human
  • Receptors, Purinergic P2
  • Receptors, Purinergic P2Y12
  • Adenosine Diphosphate