Genetic mapping using haplotype and model-free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31-33

Am J Med Genet B Neuropsychiatr Genet. 2004 Feb 15;125B(1):83-6. doi: 10.1002/ajmg.b.20091.

Abstract

We report further evidence for our previous suggestion [Garner et al., 2001: Am J Hum Genet 68:1061-1064] of a locus on 5q predisposing to bipolar I disorder (BP-I) in an extended Costa Rican pedigree. We genotyped additional microsatellite markers in this region and applied a multi-point non-parametric linkage analysis (SimWalk2). Significant identity-by-descent allele sharing among affected relatives was observed for all of the 20 markers tested in a segment of approximately 15 cM. Most affected individuals shared a single haplotype over this region; breaks within this haplotype may suggest a more restricted candidate location for a BP-I gene. These results support the suggestion that a locus at 5q31-33, together with a previously reported locus at 18q22-23, may provide the major genetic risk for BP-I in this family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bipolar Disorder / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 18 / genetics*
  • Chromosomes, Human, Pair 5 / genetics*
  • Costa Rica
  • Disease Susceptibility
  • Female
  • Haplotypes / genetics*
  • Humans
  • Male
  • Microsatellite Repeats / genetics
  • Pedigree*
  • Polymorphism, Single Nucleotide / genetics