Chemoprevention of prostate cancer with selenium: an update on current clinical trials and preclinical findings

J Cell Biochem. 2004 Feb 15;91(3):443-58. doi: 10.1002/jcb.10728.


Prostate cancer is the most common cancer diagnosed and the second leading cause of cancer-related deaths in men in the United States. The etiological factors that give rise to prostate cancer are not known. Therefore, it is not possible to develop primary intervention strategies to remove the causative agents from the environment. However, secondary intervention strategies with selenium (Se) compounds and other agents represent a viable option to reduce the morbidity and mortality of prostate cancer. In this review, we discuss ongoing clinical trials. In addition, we discuss preclinical mechanistic studies that provide insights into the biochemical and molecular basis for the anti-carcinogenic activity of both inorganic and organic forms of Se.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Clinical Trials as Topic*
  • Drug Evaluation, Preclinical*
  • Eligibility Determination / classification
  • Humans
  • Male
  • Models, Biological
  • Organoselenium Compounds / metabolism
  • Prostatic Neoplasms / drug therapy*
  • Selenium / metabolism
  • Selenium / therapeutic use*
  • Sodium Selenite / metabolism
  • Vitamin E / therapeutic use


  • Organoselenium Compounds
  • Vitamin E
  • Selenium
  • Sodium Selenite