Background: Nosocomial transmission of malaria is a rare phenomenon in the United States.
Objective: To describe the probable transmission of Plasmodium falciparum malaria from a patient to a healthcare worker and then from the healthcare worker to another patient.
Design: Case series.
Setting: Two community hospitals in Massachusetts.
Intervention: Routine medical and supportive care.
Measurements: Clinical and laboratory evaluation.
Results: A nurse developed falciparum malaria after a needlestick injury from a patient with documented falciparum malaria. Three days prior to her diagnosis, she cared for another patient, who subsequently developed falciparum malaria. That patient's parasite isolate genetically matched the nurse's isolate by two independent DNA fingerprinting techniques.
Conclusion: After extensive evaluation, we believe that a nurse who had acquired falciparum malaria via needlestick subsequently transmitted malaria to another patient via a break in standard precautions. The implications of this mechanism of transmission are discussed.