Long-term outcome of kidney transplant using non-heart-beating donor: multicenter analysis of factors affecting graft survival

Clin Transplant. 2003 Dec;17(6):518-21. doi: 10.1046/j.1399-0012.2003.00080.x.

Abstract

This multicenter study was retrospectively evaluated for the predictive factors affecting the long-term graft survival of a kidney transplant from a non-heart-beating donor (NHBD).

Patients and method: A total of 706 patients received transplants from NHBD in 11 centers between 1986 and 2000 and the results were entered into the analysis. The patients were treated with cyclosporine- or tacrolimus-based immunosuppressive therapy. Graft survival was calculated by the Kaplan-Meier method. Factors selected for univariate analysis were donor age, and acute early and acute late rejection. Hypertension (HT), hyperlipidemia (HL), and diabetes mellitus were also analyzed in 638 recipients whose graft survived for more than 1 yr.

Results: In the cases using NHBD, graft survival for 1, 5, and 10 yr was 87, 69, and 53%, respectively. Donor age of over 55 yr, acute early and late rejection, post-transplant HT and diabetes at the first post-operative year were shown to be significantly harmful on long-term graft survival. For longer graft survival in NHBD kidney transplantations, reducing acute rejection, and controlling blood pressure and sugar are crucial.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Cadaver
  • Cyclosporine / therapeutic use
  • Diabetes Mellitus / epidemiology
  • Follow-Up Studies
  • Graft Rejection / epidemiology
  • Graft Rejection / prevention & control
  • Graft Survival*
  • Humans
  • Hyperlipidemias / epidemiology
  • Hypertension / epidemiology
  • Immunosuppressive Agents / therapeutic use
  • Kidney Failure, Chronic / surgery*
  • Retrospective Studies
  • Risk Factors
  • Tacrolimus / therapeutic use
  • Time Factors
  • Tissue Donors

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Tacrolimus