Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains

Brain Res Dev Brain Res. 2004 Jan 31;148(1):151-5. doi: 10.1016/j.devbrainres.2003.11.008.

Abstract

In human brain, developmental up-regulation in RNA editing at the Q/R site was evident in GluR5 and GluR6, but GluR2 editing in the white matter was down-regulated. Each ADAR mRNA expression was up-regulated in the gray matter, whereas differently regulated in the white matter. ADAR2 mRNA was not overexpressed in the brains of Down's syndrome subjects, nor was there any evidence of changes in the RNA editing efficiency of their GluRs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Deaminase / biosynthesis*
  • Adenosine Deaminase / genetics
  • Adult
  • Aged
  • Brain / anatomy & histology
  • Brain / growth & development
  • Brain / metabolism*
  • Down Syndrome / genetics*
  • Down Syndrome / metabolism
  • Female
  • Gene Expression Regulation, Developmental / physiology*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • RNA Editing / physiology*
  • RNA, Messenger / biosynthesis
  • RNA-Binding Proteins
  • Receptors, Glutamate / genetics*

Substances

  • RNA, Messenger
  • RNA-Binding Proteins
  • Receptors, Glutamate
  • ADARB1 protein, human
  • Adenosine Deaminase