Neuroendocrine aspects of chronic fatigue syndrome

Neuroimmunomodulation. 2004;11(2):65-74. doi: 10.1159/000075315.


Chronic fatigue syndrome (CFS) is a serious health concern affecting over 800000 Americans of all ages, races, socioeconomic groups and genders. The etiology and pathophysiology of CFS are unknown, yet studies have suggested an involvement of the neuroendocrine system. A symposium was organized in March 2001 to explore the possibility of an association between neuroendocrine dysfunction and CFS, with special emphasis on the interactions between neuroendocrine dysfunction and other abnormalities noted in the immune and autonomic nervous systems of individuals with CFS. This paper represents the consensus of the panel of experts who participated in this meeting.

Publication types

  • Consensus Development Conference
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Autonomic Nervous System / metabolism
  • Autonomic Nervous System / physiopathology
  • Depression / physiopathology
  • Fatigue Syndrome, Chronic / metabolism*
  • Fatigue Syndrome, Chronic / physiopathology*
  • Humans
  • Hypothalamo-Hypophyseal System / metabolism
  • Hypothalamo-Hypophyseal System / physiopathology
  • Immune System / metabolism
  • Immune System / physiopathology
  • Neurosecretory Systems / metabolism*
  • Neurosecretory Systems / physiopathology*
  • Sleep Wake Disorders / immunology
  • Sleep Wake Disorders / metabolism
  • Sleep Wake Disorders / physiopathology
  • Stress, Physiological / complications
  • Stress, Physiological / immunology