Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002;19(7-9):543-9.
doi: 10.1023/B:GLYC.0000014084.01324.15.

Galectin-3 and Metastasis

Affiliations
Review

Galectin-3 and Metastasis

Yukinori Takenaka et al. Glycoconj J. .

Abstract

Galectin-3, a 31 kDa member of the beta-galactoside-binding proteins, is an intracellular and extracellular lectin which interacts with intracellular glycoproteins, cell surface molecules and extracellular matrix proteins. Galectin-3 is expressed widely in epithelial and immune cells and its expression is correlated with cancer aggressiveness and metastasis. Galectin-3 is involved in various biological phenomena including cell growth, adhesion, differentiation, angiogenesis and apoptosis. Recent research revealed that galectin-3 is associated with several steps of invasion and metastasis, like angiogenesis, cell-matrix interaction, dissemination through blood flow and extravasation. Recently, we and others have shown that galectin-3 can be a reliable diagnostic marker in certain cancers and one of the target proteins of cancer treatment. In this review, we describe the involvement of galectin-3 in each steps of metastasis and clinical significance of galectin-3.

Similar articles

See all similar articles

Cited by 94 articles

See all "Cited by" articles

References

    1. J Pathol. 1996 May;179(1):43-8 - PubMed
    1. Int J Cancer. 1982 Jul 15;30(1):107-12 - PubMed
    1. Am J Pathol. 1995 Sep;147(3):815-22 - PubMed
    1. J Biol Chem. 1990 May 5;265(13):7097-9 - PubMed
    1. Cancer Metastasis Rev. 1987;6(3):433-52 - PubMed

LinkOut - more resources

Feedback