Hormonal profile of men with premature balding

Exp Clin Endocrinol Diabetes. 2004 Jan;112(1):24-8. doi: 10.1055/s-2004-815723.


Objective: Premature androgenic alopecia has been suggested as a feature of the male equivalent of the syndrome of polycystic ovary. However, the hormonal pattern of men with premature balding has been investigated in only a few studies with inconsistent results.

Material and methods: We examined 37 men with premature balding (defined as frontoparietal and vertex hair loss before the age of 30 years with alopecia defined as grade 3 vertex or more on the alopecia classification scale of Hamilton with Norwood modification). The plasma concentrations of total testosterone, dihydrotestosterone, epitestosterone, androstenedione, cortisol, 17-OH-progesterone (17OHP), estradiol, LH, FSH, prolactin, SHBG and TSH and free thyroxine were measured.

Results: The frequency of subnormal values in SHBG, FSH, testosterone and epitestosterone (but not in free androgen index) was significant in the balding men. A borderline significant trend was recorded with respect to increased levels in 17OH-P and prolactin.

Conclusions: The hormonal pattern of a substantial number of men with premature balding resembles in some respects the hormonal pattern of women with polycystic ovary syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alopecia / blood*
  • Gonadal Steroid Hormones / blood
  • Hormones / blood*
  • Humans
  • Male
  • Pituitary Hormones / blood
  • Sex Hormone-Binding Globulin / metabolism
  • Thyroxine / blood


  • Gonadal Steroid Hormones
  • Hormones
  • Pituitary Hormones
  • Sex Hormone-Binding Globulin
  • Thyroxine