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, 52 (3), 451-5

Polyozellin Isolated From Polyozellus Multiplex Induces Phase 2 Enzymes in Mouse Hepatoma Cells and Differentiation in Human Myeloid Leukaemic Cell Lines

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Polyozellin Isolated From Polyozellus Multiplex Induces Phase 2 Enzymes in Mouse Hepatoma Cells and Differentiation in Human Myeloid Leukaemic Cell Lines

Jeong Hyun Kim et al. J Agric Food Chem.

Abstract

Induction of cellular phase 2 detoxifying enzymes is associated with cancer preventive potential. Quinone reductase (QR) has been used as a prototype for anticarcinogenic phase 2 enzymes because of its widespread distribution in mammalian systems, large amplitude of inducer response, and ease of measurement in murine hepatoma cells. Methanol extract of Polyozellus multiplex, which shows a strong QR induction potential, was subjected to bioassay-guided fractionation, and polyozellin (PM1) appeared to be a major active component. In in vitro cultured cells (hepa1c1c7 and BPRc1 cells), polyozellin enhanced QR, glutathione S-transferase (GST) activities, and glutathione (GSH) content in a dose-dependent manner. The compound also significantly promoted differentiation of HL-60 human promyelocytic emia cells. In conclusion, polyozellin deserves further in vivo study to evaluate its potential as a cancer preventive agent.

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