Abstract
It is believed that caffeine attenuates the coronary hyperemic response to adenosine by blocking the A2a receptors. We studied the effect of caffeine on adenosine-induced myocardial hyperemia measured by fractional flow reserve after intracoronary adenosine administration. Fractional flow reserve was not affected by intravenous caffeine infusion at a dose that was comparable to oral consumption.
MeSH terms
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Adenosine / administration & dosage*
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Adenosine A2 Receptor Antagonists*
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Adult
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Caffeine / administration & dosage*
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Coronary Artery Disease / physiopathology*
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Hemodynamics / drug effects
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Humans
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Hyperemia / physiopathology*
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Infusions, Intravenous
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Injections, Intra-Arterial
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Male
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Middle Aged
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Pilot Projects
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Vasodilator Agents / administration & dosage*
Substances
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Adenosine A2 Receptor Antagonists
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Vasodilator Agents
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Caffeine
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Adenosine