Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease

Am J Cardiol. 2004 Feb 1;93(3):343-6. doi: 10.1016/j.amjcard.2003.10.017.

Abstract

It is believed that caffeine attenuates the coronary hyperemic response to adenosine by blocking the A2a receptors. We studied the effect of caffeine on adenosine-induced myocardial hyperemia measured by fractional flow reserve after intracoronary adenosine administration. Fractional flow reserve was not affected by intravenous caffeine infusion at a dose that was comparable to oral consumption.

Publication types

  • Clinical Trial

MeSH terms

  • Adenosine / administration & dosage*
  • Adenosine A2 Receptor Antagonists*
  • Adult
  • Caffeine / administration & dosage*
  • Coronary Artery Disease / physiopathology*
  • Hemodynamics / drug effects
  • Humans
  • Hyperemia / physiopathology*
  • Infusions, Intravenous
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Pilot Projects
  • Vasodilator Agents / administration & dosage*

Substances

  • Adenosine A2 Receptor Antagonists
  • Vasodilator Agents
  • Caffeine
  • Adenosine