Effect of direct-current cardioversion on ischemia-modified albumin levels in patients with atrial fibrillation

Am J Cardiol. 2004 Feb 1;93(3):366-8. doi: 10.1016/j.amjcard.2003.10.023.


Ischemia-modified albumin (IMA), measured with the albumin cobalt binding test, is a marker of myocardial ischemia. We measured IMA concentrations after elective direct-current cardioversion for atrial fibrillation to determine whether transient myocardial ischemia occurs. Patients with electrocardiographic changes after cardioversion (ST-depression and/or T-wave inversion) had significantly higher IMA levels than those without these changes. Thus, elevated levels of IMA after cardioversion may reflect transient myocardial ischemia.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Atrial Fibrillation / blood
  • Atrial Fibrillation / therapy*
  • Cobalt / metabolism
  • Electric Countershock / adverse effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Ischemia / blood*
  • Myocardial Ischemia / etiology*
  • Protein Binding
  • Serum Albumin / metabolism*


  • Serum Albumin
  • Cobalt