The human immunodeficiency virus (HIV) is a member of a family of retroviruses that cause chronic persistent infections in animals and in humans. The structure of this virus resembles that of other retroviruses but also contains important and complex regulatory elements. The expression of HIV can be influenced by the action of exogenous agents and cytokines. HIV has been isolated from a number of cell types, including cells in the skin, using sensitive detection methods such as the polymerase chain reaction and in situ hybridization. This article is a basic overview of the molecular biology of HIV and its presence in skin.