Distribution and Antifungal Susceptibility of Candida Species Causing Candidemia From 1996 to 1999

Diagn Microbiol Infect Dis. 2004 Jan;48(1):33-7. doi: 10.1016/j.diagmicrobio.2003.08.002.

Abstract

Susceptibilities to amphotericin B and fluconazole of 383 Candida species isolated from blood were determined. Candida albicans was the most common species (55.6%), followed by Candida parapsilosis (17.5%), Candida tropicalis (16.5%), Candida glabrata (5.2%), Candida guilliermondii (2.3%), and others (2.9%). All but three isolates, Candida ciferrii, C. tropicalis, and C. glabrata, one each, were susceptible to amphotericin B. A total of 367 (95.8%) and 15 (4.2%) isolates were susceptible and susceptible-dose dependent to fluconazole, respectively. Only one isolate, a C. glabrata, was resistant to fluconazole. Few patients (13%) having prior fluconazole treatments may explain the low rate of resistance to fluconazole in this study.

Publication types

  • Comparative Study

MeSH terms

  • Amphotericin B / pharmacology*
  • Candida / classification*
  • Candida / drug effects*
  • Candidiasis / drug therapy
  • Drug Resistance, Fungal
  • Fluconazole / pharmacology*
  • Fungemia / drug therapy
  • Fungemia / microbiology
  • Humans
  • Microbial Sensitivity Tests
  • Retrospective Studies
  • Sampling Studies
  • Sensitivity and Specificity

Substances

  • Amphotericin B
  • Fluconazole