In vitro interactions of licensed and novel antifungal drugs against Fusarium spp

Diagn Microbiol Infect Dis. 2004 Jan;48(1):69-71. doi: 10.1016/j.diagmicrobio.2003.09.003.

Abstract

We have studied the in vitro interactions of amphotericin B (AMB) with terbinafine (TBF), itraconazole, voriconazole (VCZ), albaconazole, and ravuconazole (RVZ), as well as TBF combined with the same azoles, against 11 isolates of Fusarium spp. using the fractional inhibitory concentration index. The highest percentage of synergistic interactions was observed for the combinations AMB-RVZ, TBF-VCZ, and TBF-RCZ.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology*
  • Antifungal Agents / pharmacology*
  • Drug Interactions
  • Drug Resistance, Fungal
  • Fusarium / classification
  • Fusarium / drug effects*
  • Humans
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests
  • Naphthalenes / pharmacology
  • Pyrimidines / pharmacology
  • Quinazolines / pharmacology
  • Sensitivity and Specificity
  • Terbinafine
  • Thiazoles / pharmacology
  • Triazoles / pharmacology
  • Voriconazole

Substances

  • Antifungal Agents
  • Naphthalenes
  • Pyrimidines
  • Quinazolines
  • Thiazoles
  • Triazoles
  • Itraconazole
  • Amphotericin B
  • ER 30346
  • Terbinafine
  • Voriconazole
  • albaconazole