Himalomycin A and B: isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate
- PMID: 14763560
- DOI: 10.7164/antibiotics.56.942
Himalomycin A and B: isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate
Abstract
In our screening of marine Streptomycetes for bioactive compounds, in addition to the known metabolites rabelomycin (1), fridamycin D (2b), N-benzylacetamide and N-(2'-phenylethyl)acetamide, two new anthracycline antibiotics designated as himalomycin A (2c) and B (2d) were isolated from the culture broth of the marine Streptomyces sp. isolate B6921. The structure of the new antibiotics was determined by comparison of the NMR data with those of fridamycin D (2b) and by detailed interpretation of mass, 1D and 2D NMR spectra.
Similar articles
-
Chalcomycin B, a new macrolide antibiotic from the marine isolate Streptomyces sp. B7064.J Antibiot (Tokyo). 2002 Oct;55(10):893-8. doi: 10.7164/antibiotics.55.893. J Antibiot (Tokyo). 2002. PMID: 12523822
-
Aranciamycin anhydride, a new anthracycline-type antibiotic isolated from Streptomyces sp. Tü 6384(*).J Antibiot (Tokyo). 2010 Jul;63(7):397-9. doi: 10.1038/ja.2010.59. Epub 2010 Jun 16. J Antibiot (Tokyo). 2010. PMID: 20551987 No abstract available.
-
A new anthracycline-type metabolite from Streptomyces sp. NEAU-L3.J Antibiot (Tokyo). 2017 Oct;70(10):1026-1028. doi: 10.1038/ja.2017.95. Epub 2017 Aug 16. J Antibiot (Tokyo). 2017. PMID: 28811620
-
Cervinomycins C1-4 with cytotoxic and antibacterial activity from Streptomyces sp. CPCC 204980.J Antibiot (Tokyo). 2020 Dec;73(12):812-817. doi: 10.1038/s41429-020-0342-1. Epub 2020 Jul 3. J Antibiot (Tokyo). 2020. PMID: 32616897
-
Parimycin: isolation and structure elucidation of a novel cytotoxic 2,3-dihydroquinizarin analogue of gamma-indomycinone from a marine streptomycete isolate.J Antibiot (Tokyo). 2002 Dec;55(12):1031-5. doi: 10.7164/antibiotics.55.1031. J Antibiot (Tokyo). 2002. PMID: 12617511
Cited by
-
A comprehensive review of glycosylated bacterial natural products.Chem Soc Rev. 2015 Nov 7;44(21):7591-697. doi: 10.1039/c4cs00426d. Chem Soc Rev. 2015. PMID: 25735878 Free PMC article. Review.
-
Integrated Metabolomic, Molecular Networking, and Genome Mining Analyses Uncover Novel Angucyclines From Streptomyces sp. RO-S4 Strain Isolated From Bejaia Bay, Algeria.Front Microbiol. 2022 Jun 23;13:906161. doi: 10.3389/fmicb.2022.906161. eCollection 2022. Front Microbiol. 2022. PMID: 35814649 Free PMC article.
-
De novo asymmetric synthesis of fridamycin E.Org Lett. 2011 Dec 16;13(24):6592-5. doi: 10.1021/ol203041b. Epub 2011 Nov 22. Org Lett. 2011. PMID: 22107019 Free PMC article.
-
Deciphering the Glycosylation Steps in the Biosynthesis of P-1894B and Grincamycin Isolated from Marine-Derived Streptomyces lusitanus SCSIO LR32.Mar Drugs. 2024 Jan 2;22(1):32. doi: 10.3390/md22010032. Mar Drugs. 2024. PMID: 38248657 Free PMC article.
-
Marine Bacterial Compounds Evaluated by In Silico Studies as Antipsychotic Drugs Against Schizophrenia.Mar Biotechnol (NY). 2018 Oct;20(5):639-653. doi: 10.1007/s10126-018-9835-3. Epub 2018 Jul 18. Mar Biotechnol (NY). 2018. PMID: 30019186
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
