Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach

J Clin Endocrinol Metab. 2004 Feb;89(2):463-78. doi: 10.1210/jc.2003-030723.

Publication types

  • Review

MeSH terms

  • Adipocytes*
  • Animals
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / etiology*
  • Fatty Acids, Nonesterified / metabolism*
  • Humans
  • Lipid Metabolism
  • Obesity / complications*
  • Obesity / pathology
  • Receptors, Cytoplasmic and Nuclear / agonists*
  • Transcription Factors / agonists*

Substances

  • Fatty Acids, Nonesterified
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors