Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats

J Vet Intern Med. Jan-Feb 2004;18(1):43-6. doi: 10.1892/0891-6640(2004)18<43:saoaab>2.0.co;2.

Abstract

A prospective study was performed to determine the relative availability of buspirone and amitriptyline after oral and transdermal routes of administration in 6 adult cats. For topical administration, drugs were compounded in a transdermal organogel containing pluronic and lecithin (PLO). Using a crossover design, each cat received a single dose of amitriptyline (5 mg) and buspirone (2.5 mg) by the transdermal and oral route of administration with at least a 2-week washout interval between drug treatments. Blood samples were obtained at 0, 0.5, 1, 2, 4, 6, 8, 10, and 12 hours after drug administration for determination of plasma drug concentrations. Plasma concentrations of immunoreactive amitriptyline and buspirone were determined using commercial enzyme-linked immunosorbent assay (ELISA) tests. Systemic absorption of amitriptyline and buspirone administered by the transdermal route was poor compared with the oral route of administration. Until supporting pharmacokinetic data are available, veterinarians and cat owners should not rely on the transdermal route of administration for treating cats with amitriptyline or buspirone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Amitriptyline / administration & dosage
  • Amitriptyline / blood
  • Amitriptyline / pharmacokinetics*
  • Animals
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / blood
  • Anti-Anxiety Agents / pharmacokinetics*
  • Antidepressive Agents, Tricyclic / administration & dosage
  • Antidepressive Agents, Tricyclic / blood
  • Antidepressive Agents, Tricyclic / pharmacokinetics*
  • Area Under Curve
  • Biological Availability
  • Buspirone / administration & dosage
  • Buspirone / blood
  • Buspirone / pharmacokinetics*
  • Cats / metabolism*
  • Cross-Over Studies
  • Eliminative Behavior, Animal
  • Enzyme-Linked Immunosorbent Assay / veterinary
  • Female
  • Prospective Studies
  • Skin Absorption

Substances

  • Anti-Anxiety Agents
  • Antidepressive Agents, Tricyclic
  • Amitriptyline
  • Buspirone