Wnt signaling in B and T lymphocytes

Front Biosci. 2004 Jan 1;9:1000-10. doi: 10.2741/1309.


Wnt signaling has been shown to be critical for proper embryonic development as well as growth regulation of certain adult tissues. Defects in Wnt pathways have additionally been associated with a number of human cancers. However, it is only recently that a role for Wnts in the immune system has come to be appreciated. Wnts have now been shown to play significant roles in early stage development of both B and T lineage cells. Current studies suggest that proliferation and/or survival of these cells is associated with activation of the 'canonical' Wnt/beta-catenin pathway. Functional Wnt signaling appears to also occur in end stage B (plasma) cells where both the 'canonical' and the Wnt/RhoA pathways are activated. Herein, we review the current understanding of Wnt signaling in B and T cell development and the potential involvement of Wnt cascades in lymphoid neoplasia.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / physiology*
  • Humans
  • Proto-Oncogene Proteins / physiology*
  • Signal Transduction / physiology*
  • T-Lymphocytes / physiology*
  • Wnt Proteins
  • Zebrafish Proteins*


  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Zebrafish Proteins