Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid

J Clin Microbiol. 2004 Feb;42(2):929-32. doi: 10.1128/JCM.42.2.929-932.2004.

Abstract

Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid.

Publication types

  • Case Reports

MeSH terms

  • Accidents, Traffic
  • Acetamides / therapeutic use*
  • Adolescent
  • Anti-Infective Agents / therapeutic use*
  • Community-Acquired Infections / cerebrospinal fluid
  • Community-Acquired Infections / drug therapy
  • Female
  • Humans
  • Linezolid
  • Meningitis, Bacterial / cerebrospinal fluid
  • Meningitis, Bacterial / drug therapy*
  • Methicillin Resistance / genetics*
  • Oxazolidinones / therapeutic use*
  • Staphylococcal Infections / cerebrospinal fluid
  • Staphylococcal Infections / drug therapy*
  • Staphylococcus epidermidis / drug effects
  • Staphylococcus epidermidis / genetics*
  • Staphylococcus epidermidis / isolation & purification

Substances

  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid