Alternaria-induced asthma

J Allergy Clin Immunol. 2004 Feb;113(2):227-34. doi: 10.1016/j.jaci.2003.11.023.


Acute, severe asthma attacks can be precipitated by a variety of stimuli including exposure to aeroallergens, viral respiratory infections, pollutants, and occupational chemicals. Alternaria is a major aeroallergen in many parts of the world. Sensitivity to Alternaria has been increasingly recognized as a risk factor for the development and persistence of asthma, asthma severity, and potentially fatal asthma exacerbations. We present the case of a patient with IgE-mediated sensitivity to Alternaria who developed an acute, life-threatening asthma attack during the peak Alternaria season. We describe the aerobiology, pathophysiobiology, diagnosis, and treatment options for patients with Alternaria-induced asthma.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Administration, Inhalation
  • Air Microbiology
  • Air Pollution, Indoor
  • Allergens / adverse effects*
  • Allergens / immunology
  • Alternaria / immunology*
  • Asthma / diagnosis
  • Asthma / epidemiology
  • Asthma / etiology*
  • Asthma / physiopathology
  • Child
  • Humans
  • Male
  • Skin Tests


  • Allergens