The aim of the investigation was to study the variants of the course of sterile and infected pancreatonecrosis, the character of the developing complications depending on the state of organic blood circulation in the pancreas and the influence of its correction upon the outcomes of the disease. The material of examination and treatment of 121 patients with pancreatonecrosis was analyzed. Complex treatment of 51 of the patients included the method of regional intraarterial infusion. Celiacography and CT with the intraarterial contrast reinforcement have revealed that in 35 (68.6%) patients there were symptoms of "perfusion block" of the pancreas of different degrees which was due to spasm, thrombosis of the vessels and impairment of the regional microcirculation. Differentiated approach to the composition of the infusate resulted in arrest of phenomena of "perfusion block" of the pancreas in 24 out of 35 patients. As a whole, using this method allowed to reduce the number of purulent complications, primary open operations and reoperations. Lethality in the group with infusion was 9.8%.