We presented an autopsy case of a severely handicapped girl with sequelae of acute encephalopathy at 10 months old. The autopsy findings were diffuse leukomalacia in cerebral medulla, loss of nerve cells and marked gliosis in thalamus, leukomalacia with fibrous gliosis in central tegmental tracts, and marked fibrous gliosis of the cerebellar hemisphere. Purkinje cells were spared much more than granular cells. Hypertrophy of the nerve cells in the inferior olives were seen and the bundles of its efferent nerve fibers were thin. This case is worth reporting that she has suffered from brain damage about 8 years before, and the inferior olives are hypertrophic yet.