Objective: To investigate the effect of flavonoids from the seed residue and fruit residue of Hippophae rhamnoides L. (FSH and FFH) on glycometabolism in mice.
Method: The healthy male mice were randomly divided into control group, three FSH treatment groups and three FFH treatment groups. FSH(50, 100, 150 mg/kg) and FFH (50, 100, 150 mg/kg) were given intragastorically(i.g.). At the same time, the mice of control group were given physiological saline. The levels of serum glucose, serum cholesterol were determined when it lasted 7 and 14 days. After 16 days glyconeogenesis test was made and liver glycogen was analyzed.
Result: The levels of serum glucose, serum cholesterol and serum triglyceride were significantly reduced by high dose FSH and FFH. The glyconegenesis was also obviously inhibited by FSH and FFH.
Conclusion: FSH and FFH can decrease the levels of blood glucose and lipid in normal mice, and the effect of FSH and FFH on glycometabolism may be related to the control of glyconeogenesis.