Novel estrogen receptor coregulators and signaling molecules in human diseases

Cell Mol Life Sci. 2004 Feb;61(3):281-91. doi: 10.1007/s00018-003-3222-5.


The steroid hormone estrogen and signaling from its receptors are increasingly recognized as critical mediators of a variety of organ-specific biological processes. Recent advances in the identification and functional characterization of novel estrogen receptor interacting proteins clearly show the complexity of hormonal signaling regulation, but may also contribute to our understanding of the roles of estrogen signaling in normal physiology and the pathobiology of human disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bone and Bones / physiology
  • Cardiovascular Physiological Phenomena
  • Chromatin / metabolism
  • Estrogens / metabolism
  • Humans
  • Neoplasms / metabolism
  • Neuroprotective Agents / metabolism
  • Nuclear Proteins / metabolism
  • Receptors, Estrogen / metabolism*
  • Repressor Proteins / metabolism
  • Signal Transduction / physiology*


  • Chromatin
  • Estrogens
  • Neuroprotective Agents
  • Nuclear Proteins
  • Receptors, Estrogen
  • Repressor Proteins