Fixed drug eruption of the scrotum due to methylphenidate

Ann Pharmacother. 1992 Nov;26(11):1378-9. doi: 10.1177/106002809202601107.


Objective: To report two cases of fixed drug eruption induced by methylphenidate.

Case summary: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum. Drug discontinuation was followed by a complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration-inhibiting factor (MIF) assay with methylphenidate was positive.

Discussion: The pathogenesis of fixed drug eruption and the role of MIF assay in the diagnosis of adverse drug reaction is discussed.

Conclusions: Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.

Publication types

  • Case Reports

MeSH terms

  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Child
  • Drug Eruptions / etiology*
  • Genital Diseases, Male / chemically induced
  • Humans
  • Macrophage Migration-Inhibitory Factors / analysis
  • Male
  • Methylphenidate / adverse effects*
  • Methylphenidate / therapeutic use
  • Scrotum*


  • Macrophage Migration-Inhibitory Factors
  • Methylphenidate