A narrow window of intracellular calcium concentration is optimal for neurite outgrowth in rat sensory neurones

Brain Res Dev Brain Res. 1992 Dec 18;70(2):287-90. doi: 10.1016/0165-3806(92)90209-f.


We have examined neurite outgrowth in rat sensory neurones when cytosolic free calcium concentration ([Ca2+]i) was varied in the range 0-60 nM. Neurite outgrowth was maximal at 35 nM [Ca2+]i and was reduced at higher and lower values of [Ca2+]i. These results provide direct evidence for Mattson and Kater's suggestion of an optimal calcium range for growth cone function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / physiology*
  • Cell Movement
  • Egtazic Acid / analogs & derivatives
  • Egtazic Acid / pharmacology
  • Ganglia, Spinal / physiology
  • Intracellular Fluid / physiology
  • Neurites / physiology*
  • Neurons, Afferent / physiology*
  • Rats
  • Rats, Sprague-Dawley


  • Egtazic Acid
  • 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
  • Calcium