Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

Genomics. 1992 Dec;14(4):1104-6. doi: 10.1016/s0888-7543(05)80138-7.

Abstract

The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3' untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoradiography
  • Base Sequence
  • Carrier Proteins / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 15*
  • DNA / genetics
  • Dopamine Plasma Membrane Transport Proteins
  • Humans
  • Hybrid Cells
  • In Situ Hybridization
  • Membrane Glycoproteins / genetics*
  • Membrane Transport Proteins*
  • Molecular Sequence Data
  • Nerve Tissue Proteins*
  • Repetitive Sequences, Nucleic Acid
  • Rodentia

Substances

  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A3 protein, human
  • DNA