Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

Genomics. 1992 Dec;14(4):1110-1. doi: 10.1016/s0888-7543(05)80140-5.

Abstract

The gene for human P450(17 alpha) (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17 alpha-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Banding*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 10*
  • Cytochrome P-450 Enzyme System / genetics*
  • DNA
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Karyotyping
  • Steroid 17-alpha-Hydroxylase / genetics*

Substances

  • DNA
  • Cytochrome P-450 Enzyme System
  • Steroid 17-alpha-Hydroxylase
  • pregnenolone 17-alpha-hydroxylase