Allergic contact dermatitis from formaldehyde resins in permanent press clothing: an underdiagnosed cause of generalized dermatitis

J Am Acad Dermatol. 1992 Dec;27(6 Pt 1):962-8. doi: 10.1016/0190-9622(92)70295-q.


Background and methods: Formaldehyde resins have been used to impart wrinkle resistance to clothing fabrics since 1926. After several patients with positive patch tests to formaldehyde resins had been examined, a study was undertaken of the records of all patch tests performed at the University of Louisville Patch Test Clinic and the Allergy Section of the Skin and Cancer Clinic of New York University Medical Center from January 1988 through April 1990 to determine the prevalence of positive patch-test reactions to formaldehyde-based textile resins and the clinical and demographic patterns associated with textile resin allergy.

Results: Seventeen patients were identified at the two centers. Twelve were allergic to formaldehyde as well as to formaldehyde textile resins. Several clinical patterns were found, including accentuation of dermatitis in areas of tight clothing, primary occurrence in clothing-covered areas, and a chronic recalcitrant course. Ethylene urea melamine formaldehyde resin was the best screening agent with 14 definite positive reactions and one equivocal reaction.

Conclusion: Formaldehyde textile resin allergy is more common than has been previously recognized. Patch testing with one or more formaldehyde textile resins is indicated in patients with a particular pattern of dermatitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Clothing / adverse effects*
  • Dermatitis, Allergic Contact / etiology*
  • Female
  • Formaldehyde / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Patch Tests
  • Resins, Synthetic / adverse effects*
  • Retrospective Studies
  • Textiles / adverse effects*


  • Resins, Synthetic
  • Formaldehyde