Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid

Neurosci Lett. 1992 Nov 23;147(1):9-12. doi: 10.1016/0304-3940(92)90762-v.


We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Multiple Sclerosis / cerebrospinal fluid*
  • Nerve Growth Factors / cerebrospinal fluid*
  • Reference Values


  • Nerve Growth Factors