An overview of methods for the analysis of longitudinal data

Stat Med. 1992 Oct-Nov;11(14-15):1825-39. doi: 10.1002/sim.4780111406.


This paper reviews statistical methods for the analysis of discrete and continuous longitudinal data. The relative merits of longitudinal and cross-sectional studies are discussed. Three approaches, marginal, transition and random effects models, are presented with emphasis on the distinct interpretations of their coefficients in the discrete data case. We review generalized estimating equations for inferences about marginal models. The ideas are illustrated with analyses of a 2 x 2 crossover trial with binary responses and a randomized longitudinal study with a count outcome.

MeSH terms

  • Cross-Sectional Studies
  • Humans
  • Linear Models
  • Longitudinal Studies*
  • Mathematical Computing
  • Models, Statistical*
  • Random Allocation
  • Statistics as Topic / methods