Lelystad virus, the cause of porcine epidemic abortion and respiratory syndrome: a review of mystery swine disease research at Lelystad

G Wensvoort; E P de Kluyver; J M Pol; F Wagenaar; R J Moormann; M M Hulst; R Bloemraad; A den Besten; T Zetstra; C Terpstra

doi:10.1016/0378-1135(92)90046-v

Lelystad virus, the cause of porcine epidemic abortion and respiratory syndrome: a review of mystery swine disease research at Lelystad

Vet Microbiol. 1992 Nov;33(1-4):185-93. doi: 10.1016/0378-1135(92)90046-v.

Authors

G Wensvoort¹, E P de Kluyver, J M Pol, F Wagenaar, R J Moormann, M M Hulst, R Bloemraad, A den Besten, T Zetstra, C Terpstra

Affiliation

¹ Central Veterinary Institute, Department of Virology, Lelystad, Netherlands.

PMID: 1481355
DOI: 10.1016/0378-1135(92)90046-v

Abstract

This paper reviews the laboratory investigations that led us to isolate the Lelystad virus and demonstrate that this virus causes mystery swine disease. We describe: 1) isolating the virus from the disease; 2) characterizing the virus as a new enveloped RNA virus; 3) reproducing the disease experimentally with the isolated Lelystad virus; 4) isolating the virus from the experimentally induced disease.

MeSH terms

Abortion, Veterinary / microbiology*
Animals
Cell Line
Cells, Cultured
Chick Embryo
Female
Pregnancy
RNA Viruses / classification
RNA Viruses / isolation & purification*
RNA Viruses / physiology
Respiratory Tract Infections / microbiology
Respiratory Tract Infections / veterinary*
Swine
Swine Diseases / microbiology*
Virus Diseases / microbiology*