Abdominal vagal mediation of the satiety effects of exogenous and endogenous cholecystokinin in rats

Am J Physiol. 1992 Dec;263(6 Pt 2):R1354-8. doi: 10.1152/ajpregu.1992.263.6.R1354.


The hypothesis that peripherally administered cholecystokinin C-terminal octapeptide (CCK-8) and endogenous CCK act by the same abdominal vagal mechanism to produce satiety was tested by injecting rats with CCK-8 or the type A CCK receptor antagonist MK-329 after they had received bilateral subdiaphragmatic vagotomies. CCK-8 (8 nmol/kg ip) inhibited 1-h food intake by 60%; vagotomy and MK-329 (0.5 mg/kg sc) each completely blocked this effect. In contrast, vagotomy did not alter the stimulatory effect of MK-329 (0.5 mg/kg sc) on feeding; 3-h cumulative intake in control and vagotomized animals was increased by 25 and 34%, respectively. These results suggest that satiety is mediated in part by an endogenous CCK action that is independent of abdominal vagal innervation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Abdomen / innervation
  • Animals
  • Benzodiazepinones / pharmacology
  • Cholecystokinin / antagonists & inhibitors
  • Cholecystokinin / physiology*
  • Devazepide
  • Eating / drug effects
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Satiety Response* / drug effects
  • Satiety Response* / physiology
  • Sincalide / pharmacology*
  • Vagotomy
  • Vagus Nerve / physiology*


  • Benzodiazepinones
  • Cholecystokinin
  • Devazepide
  • Sincalide