Structural organization of the mouse lactoferrin gene

Biochem Biophys Res Commun. 1992 Dec 30;189(3):1725-31. doi: 10.1016/0006-291x(92)90277-r.

Abstract

The complete structure of the mouse lactoferrin gene is presented. Mouse lactoferrin (mLF) is encoded by a single copy gene of approximately 30 kilobases (kb) in size. The gene is organized into 17 exons separated by 16 introns. The exons range in size from 48 base pairs (bp) to 190 bp whereas the introns range from 0.2 kb to 4.3 kb. Structural analysis of the mouse lactoferrin gene reveals that this gene shares a similar intron-exon distribution pattern with both human transferrin and chicken ovotransferrin.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Blotting, Southern
  • Chickens
  • Cloning, Molecular / methods
  • Conalbumin / genetics
  • DNA / genetics*
  • DNA / isolation & purification
  • Exons
  • Genomic Library
  • Humans
  • Introns
  • Lactoferrin / genetics*
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction / methods
  • RNA Splicing
  • Restriction Mapping
  • Transferrin / genetics

Substances

  • Transferrin
  • Conalbumin
  • DNA
  • Lactoferrin