Interleukin-1 alpha: regulation of cellular proliferation and collagen synthesis in cultured human osteoblast-like cells

Cell Mol Biol (Noisy-le-grand). 1992 Aug-Sep;38(5-6):679-86.

Abstract

In this work the authors studied the effects of interleukin-1 alpha on metabolic activities of human osteoblast-like cells in vitro. The bone nature of the cells was established by assaying for specific bone protein, the osteonectin, and the parathormone receptor, an osteoblast marker. Administration of interleukin-1 alpha to cultured osteoblasts produce an increase in cellular proliferation as suggested by 3H-thymidine incorporation and cell growth studies. Interleukin-1 alpha also affected collagen synthesis confirming its potential role on bone-formation and resorption processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Adult
  • Cell Division / drug effects*
  • Cells, Cultured
  • Collagen / biosynthesis*
  • DNA / biosynthesis
  • Dose-Response Relationship, Drug
  • Humans
  • Interleukin-1 / pharmacology*
  • Leucine / metabolism
  • Osteoblasts / cytology*
  • Osteoblasts / drug effects
  • Osteoblasts / metabolism*
  • Parathyroid Hormone / pharmacology
  • Propranolol / pharmacology
  • Protein Biosynthesis
  • Recombinant Proteins / pharmacology
  • Thymidine / metabolism
  • Tritium

Substances

  • Interleukin-1
  • Parathyroid Hormone
  • Recombinant Proteins
  • Tritium
  • Collagen
  • DNA
  • Propranolol
  • Adenylyl Cyclases
  • Leucine
  • Thymidine