The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration

J Neurosci Res. 1992 Dec;33(4):505-12. doi: 10.1002/jnr.490330402.


Microtubule associated protein 2 (MAP-2) historically has been perceived primarily as a static, structural protein, necessary along with other cytoskeletal proteins to maintain neuroarchitecture but somewhat removed from the "mainstream" of neuronal response mechanisms. Quite to the contrary, MAP-2 is exquisitely sensitive to many inputs and recent investigations have revealed dynamic functions for MAP-2 in the growth, differentiation, and plasticity of neurons, with key roles in neuronal responses to growth factors, neurotransmitters, synaptic activity, and neurotoxins. These discoveries indicate that modification and rearrangement of MAP-2 is an early obligatory step in many processes which modify neuronal function.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aging / physiology
  • Animals
  • Brain / growth & development
  • Brain / physiology*
  • Brain Ischemia / physiopathology
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Microtubule-Associated Proteins / physiology*
  • Nerve Degeneration*
  • Neuronal Plasticity*
  • Neurons / cytology
  • Neurons / physiology*
  • Neurotoxins / pharmacology
  • Rats


  • Microtubule-Associated Proteins
  • Neurotoxins