Diffuse Lewy body disease presenting with supranuclear gaze palsy, parkinsonism, and dementia: a case report

Mov Disord. 1992 Oct;7(4):355-8. doi: 10.1002/mds.870070410.


A 67-year-old man with a family history of parkinsonism had visual complaints due to difficulty in convergence, which was followed 2 years later by development of bradykinesia and rigidity. The diagnosis of Steele-Richardson-Olszewski syndrome was made on the basis of a supranuclear gaze palsy, bradykinesia, rigidity, and poor response to levodopa. However, subsequent neuropathological examination revealed diffuse Lewy body disease with no evidence of neurofibrillary tangles involving either subcortical or brain stem structures.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / pathology
  • Brain / pathology
  • Dementia / diagnosis*
  • Dementia / pathology
  • Diagnosis, Differential
  • Eye Movements / physiology*
  • Humans
  • Lewy Bodies / ultrastructure
  • Male
  • Neurologic Examination
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / pathology
  • Parkinson Disease, Secondary / diagnosis*
  • Parkinson Disease, Secondary / pathology
  • Supranuclear Palsy, Progressive / diagnosis*
  • Supranuclear Palsy, Progressive / pathology