Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase

Mol Carcinog. 1992;6(4):238-42. doi: 10.1002/mc.2940060404.


Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation-, but not chemically-induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Cell Transformation, Neoplastic / metabolism*
  • Dose-Response Relationship, Radiation
  • Free Radical Scavengers
  • Gamma Rays
  • Humans
  • Mice
  • Mice, Inbred C3H
  • Microscopy, Immunoelectron
  • Mitochondria / enzymology*
  • Mitochondria / ultrastructure
  • Neoplasm Transplantation
  • Neoplasms, Radiation-Induced / pathology
  • Neoplasms, Radiation-Induced / prevention & control*
  • Sarcoma, Experimental / pathology
  • Sarcoma, Experimental / prevention & control*
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism*
  • Transfection


  • Free Radical Scavengers
  • Superoxide Dismutase