Marchiafava-Bignami disease. A case studied by structural and functional brain imaging

Eur Arch Psychiatry Clin Neurosci. 1992;242(2-3):69-71. doi: 10.1007/BF02191548.


Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism. The clinical features, X-ray, CT and MRI findings are well documented. However, functional brain imaging has not been used in cases of MBD. We used single-photon emission computed tomography (SPECT) to monitor the regional cerebral blood flow in a patient suffering from a acute form of MBD, from which he subsequently recovered. Several abnormalities were found. A more frequent use of functional brain imaging in MBD could improve our knowledge of pathogenesis and prognosis for MBD.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alcoholism / complications*
  • Brain Diseases / diagnosis
  • Brain Diseases / etiology
  • Brain Diseases / physiopathology*
  • Corpus Callosum / diagnostic imaging
  • Corpus Callosum / physiopathology*
  • Electroencephalography
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neurologic Examination
  • Radiography
  • Tomography, Emission-Computed, Single-Photon