Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine

Brain Res. 1992 Dec 11;598(1-2):321-6. doi: 10.1016/0006-8993(92)90201-j.


Methamphetamine (m-AMPH) or saline was repeatedly administered to rats. One week later, the caudate-putamen of the m-AMPH-treated rats revealed a decrease in both [3H]mazindol-labeled dopamine uptake sites and tissue dopamine content. Moreover, the resulting pattern of decline in these measures was regionally heterogeneous. The ventral caudate-putamen displayed the greatest decrease in both [3H]mazindol binding and dopamine content while the neighboring nucleus accumbens and the dorsal caudate-putamen remained relatively intact. These results indicate a regional difference in the susceptibility of striatal dopaminergic terminals to the neurotoxic effects of methamphetamine.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Transport / drug effects
  • Corpus Striatum / drug effects*
  • Dopamine / metabolism*
  • Male
  • Methamphetamine / toxicity*
  • Radioligand Assay
  • Rats
  • Rats, Sprague-Dawley


  • Methamphetamine
  • Dopamine