Nephrogenic fibrosing dermopathy in pediatric patients

Pediatr Nephrol. 2004 Apr;19(4):467-70. doi: 10.1007/s00467-003-1380-1. Epub 2004 Feb 10.

Abstract

Nephrogenic fibrosing dermopathy (NFD) is a rare and recently recognized sclerosing skin disorder of unknown etiology. Reported cases have occurred in patients with chronic renal failure, with or without renal replacement therapy. All previous cases have been reported in older adult patients. We describe two pediatric patients who recently developed this condition and review the existing literature for NFD. Our patients included an 8-year-old boy on peritoneal dialysis with no prior renal transplant and a 19-year-old boy on hemodialysis with a history of previous failed renal transplants. We speculate that the recent emergence of this condition and occurrence in patients with chronic renal failure suggest an association with some newer pharmacological agent that has recently come into wide use. Since both our patients also had previously experienced large vessel thrombosis, hypercoagulable states may also be implicated.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Child
  • Diagnosis, Differential
  • Epoxy Compounds / therapeutic use
  • Humans
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / drug therapy
  • Male
  • Peritoneal Dialysis
  • Polyamines
  • Polyethylenes / therapeutic use
  • Renal Dialysis
  • Sclerosis / complications*
  • Sclerosis / physiopathology*
  • Sevelamer
  • Skin Diseases / complications*
  • Skin Diseases / physiopathology*

Substances

  • Epoxy Compounds
  • Polyamines
  • Polyethylenes
  • Sevelamer