Dethymicin, a novel immunosuppressant isolated from an Amycolatopsis. Fermentation, isolation, physico-chemical properties and biological activities

M Ueno; M Iijima; T Masuda; N Kinoshita; H Iinuma; H Naganawa; M Hamada; M Ishizuka; T Takeuchi

doi:10.7164/antibiotics.45.1819

Dethymicin, a novel immunosuppressant isolated from an Amycolatopsis. Fermentation, isolation, physico-chemical properties and biological activities

J Antibiot (Tokyo). 1992 Dec;45(12):1819-26. doi: 10.7164/antibiotics.45.1819.

Authors

M Ueno¹, M Iijima, T Masuda, N Kinoshita, H Iinuma, H Naganawa, M Hamada, M Ishizuka, T Takeuchi

Affiliation

¹ Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.

PMID: 1490872
DOI: 10.7164/antibiotics.45.1819

Abstract

In the course of screening for immunomodulators inhibiting the mixed lymphocyte culture reaction (MLCR), we found a novel immunosuppressant, dethymicin in mycelium of Amycolatopsis mediterranei MI710-51F6. From physico-chemical properties and biological activity it is different from immunosuppressants produced by microorganisms such as cyclosporins, FK506 and rapamycin. It inhibited immune responses in vitro and in vivo, and prolonged skin allograft in rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinomycetales / chemistry*
Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology*
Cytotoxicity, Immunologic / drug effects
Female
Graft Rejection
Hypersensitivity, Delayed / drug therapy
Immunosuppressive Agents / chemistry
Immunosuppressive Agents / isolation & purification*
Immunosuppressive Agents / pharmacology*
Lymphocyte Activation / drug effects
Lymphocyte Culture Test, Mixed
Mice
Microbial Sensitivity Tests
Microbiological Techniques

Substances

Anti-Bacterial Agents
Immunosuppressive Agents