Sex hormones in postmenopausal HLA-identical rheumatoid arthritis discordant sibling pairs

J Rheumatol. 1992 Nov;19(11):1663-7.


Dehydroepiandrosterone sulfate (DHEAS), testosterone, androstenedione, 17-beta estradiol and sex hormone binding globulin have been assayed in 50 HLA-identical postmenopausal rheumatoid arthritis (RA) discordant sibling pairs. The only difference was for DHEAS, siblings with RA having a significantly lower level than their sisters. However, in 68 patients with RA, the level of DHEAS inversely correlated with disease duration, a radiographic grading score, the Health Assessment Questionnaire score, duration of morning stiffness, and a clinical score of disease activity and severity (the Spread/Severity index). These observations, taken with that of previous work on DHEAS, suggest that low levels may be a consequence of RA rather than predisposing to the disease. The role of sex hormones in RA will have to be approached in alternative ways.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Androstenedione / blood*
  • Arthritis, Rheumatoid / blood*
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / immunology*
  • Dehydroepiandrosterone / analogs & derivatives*
  • Dehydroepiandrosterone / blood
  • Dehydroepiandrosterone Sulfate
  • Estradiol / blood*
  • Female
  • HLA Antigens / genetics*
  • Health Surveys
  • Humans
  • Menopause / blood*
  • Middle Aged
  • Severity of Illness Index
  • Sex Hormone-Binding Globulin / analysis*
  • Surveys and Questionnaires
  • Testosterone / blood*
  • Twins / genetics*


  • HLA Antigens
  • Sex Hormone-Binding Globulin
  • Testosterone
  • Androstenedione
  • Dehydroepiandrosterone
  • Estradiol
  • Dehydroepiandrosterone Sulfate