Developmental changes in distribution of NMDA receptor channel subunit mRNAs

Neuroreport. 1992 Dec;3(12):1138-40. doi: 10.1097/00001756-199212000-00027.


In situ hybridization analyses have revealed drastic changes in expression and distribution of five subunit mRNAs of the mouse NMDA receptor channel during brain development. The epsilon 1 subunit mRNA is expressed postnatally and widely in the brain. On the other hand, the epsilon 2 subunit mRNA is found throughout the entire embryonic brain, but its expression becomes restricted to the forebrain at postnatal stages. The epsilon 3 subunit mRNA appears postnatally and predominantly in the cerebellum, whereas the epsilon 4 subunit mRNA is abundantly expressed in the diencephalon and the brainstem at embryonic and neonatal stages. In contrast, the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / growth & development*
  • Brain Chemistry / physiology
  • Female
  • In Situ Hybridization
  • Mice
  • Mice, Inbred C57BL
  • Oligonucleotides
  • Pregnancy
  • RNA Probes
  • RNA, Messenger / metabolism*
  • Receptors, N-Methyl-D-Aspartate / metabolism*


  • Oligonucleotides
  • RNA Probes
  • RNA, Messenger
  • Receptors, N-Methyl-D-Aspartate